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This Concept Map, created with IHMC CmapTools, has information related to: Ch 14, micrometastases must aquire ability to colonize, EMT involves detachment from adjacent epithelial cells, metastasis are initally micrometastases, micrometastases must survive despite immune response, immune response is based on recognition of expressed surface antigens, EMT can be visualized via mesenchymal markers, secondary site resulting in metastasis, EMT involves detachment from basement membrane, EMT is reversed during MET, Twist is a transcription factor, metastasis is theoretically only possible with cancer stem cells, basement membrane passage thru is determined by size, epithelial markers eg E-cadherin, extravasation into tissue at a secondary site, microvessel where they then undergo extravasation, micrometastases must survive despite lack of support, micrometastases are hard to detect, basement membrane and move into stroma, EMT can be visualized via epithelial markers, primary tumor cells must undergo EMT