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This Concept Map, created with IHMC CmapTools, has information related to: COMA Project, Creates Fractures ???? Lacerates Brain Arteries, ↑Permeability of blood vessels ???? Leakage of plasma proteins through open intracellular function, Damage to blood brain barriers ???? Leakage of lg. molecules ex) Albumin, Leakage of large molecules (i.e. Albumin) ???? H2O goes into brain tissue, Systemic dehydration ???? Cerebral Dehydration, Leakage of plasma proteins through open intracellular function ???? CEREBRAL EDEMA, ATP reliant on transport pump failure ???? Depolarization of Cells, HTN ???? ↑ICP, Influx of Ca2+ ???? Increase Intracellular Ca2+, Generation of toxic O2 free radicals ???? Necrosis+ tubular aptosis, Overexertion of Cells ???? Generation of harmful chemicals (i.e. free radicals, phospholipases), ↓Intracellular Electrolyte binding ???? ↑Influx of Electrolytes across cell membrane, Glutamate over-excite neurons ???? Overexertion of Cells, Pre-existing renal dysfunction, aging, diabetes mellitus ???? Renal Endothelial cell damage, Interruption of Parasympathetic neural transmission to eye S/Sx -Dilated pupils fail to accomodate -poor concentration -bilatateral corticospinal tract signs of increased tone and a postive babinski sign -decrease LOC, drowsiness -cheyne-stokes respirations -decorticate apperance - ipsilateral hemiplegia -arched stiff neck, pulse rate variations -paresthesias in shoulder area, compression of Diencephalon + midbrain ???? -Dilated pupils fail to accomodate -poor concentration -bilatateral corticospinal tract signs of increased tone and a postive babinski sign -decrease LOC, drowsiness -cheyne-stokes respirations -decorticate apperance - ipsilateral hemiplegia -arched stiff neck, pulse rate variations -paresthesias in shoulder area, Renal H2O loss ???? Systemic dehydration, Inflammatory Response ???? Phagocytosis of viable brain tissue, Rupture of Blood Vessels ???? Limited Blood Supply, Cascade of Neurological Changes ???? Causes Structural Brain Change