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This Concept Map, created with IHMC CmapTools, has information related to: Estrogen Receptor Signaling Pathway, Osteoblast precursor differentiation Facilitates Asymetrical Axial Bone Proliferation, Puberty Increased release of Estrogen (E2), Estrogen (E2) Binds to Estrogen Receptors in Osteoblast cells, Estrogen Receptors in Osteoblast cells Classical Pathway ER Binds to EREs Estrogen Response Elements (EREs), MAP kinase signaling pathways Regulation of Gene Transcription, Estrogen Receptors in Osteoblast cells Non-classical Pathway ER Binds to transcription factors Non EREs, Estrogen Response Elements (EREs) Located on the Regulatory domain of a Gene, Non EREs Activates MAP kinase signaling pathways, Asymetrical Axial Bone Proliferation Leading to AIS, Regulatory domain of a Gene Regulation of Gene Transcription, Gene Transcription Induction of Osteoblast precursor differentiation, Estrogen Receptors in Osteoblast cells ???? Estrogen Receptor Alpha (ERa)