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This Concept Map, created with IHMC CmapTools, has information related to: Alcohol, tremors insomnia, insomnia N.V, Delirium tremens sx Delirium = disorientation & agitation Tremens = tremors + aut. instability, fever, A/V hall., Alcohol use disorders (DSM-IV-TR) maladaptive pattern of substance use/ 12 mo/ Dependence, Alcoholic hepatitis -up to 70%. -31 times more if w/ HCV infection. Cirrhosis, Alcohol use disorders (DSM-IV-TR) How to detect? Lab for heavy drinking, Withdrawal severity more than moderate sx: 5%, Withdrawal timeline of sx start: 6-8 hrs peak: 24-28 hrs end: 7 days., Wernicke encephalopathy triad: -Ataxia -Ophtalmoplegia -Acute confusional state, Delirium tremens mortality if no adequate Tx up to 20%, Alcohol use disorders (DSM-IV-TR) signs related to alcohol Withdrawal, Withdrawal mech. decrease sensitivity of GABA & increase sensitivity of NMDA, effects (one or more) Frontal cortex impaired attention/memory, Steatosis: reversible w/ abstinence Alcoholic hepatitis, effects (one or more) cerebellum incoordination, Alcohol use disorders (DSM-IV-TR) How to detect? -Know: high prevalence & low detection. -Screening Qs eg CAGE., zero-order kinetic body metabolizes 1 drink (0.015 g/dL) per hour., Chronic medical problems mortality risk -33% for hazardous drinkers (m:4-6 drinks, f: 2-4). -50% for harmful drinkers (m:ɲ, f:ɰ)., seizures hallucinosis, more than moderate sx: 5% including Wernicke encephalopathy