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This Concept Map, created with IHMC CmapTools, has information related to: Immune Response - Complement, C3 C3b binds covalently Microbe, Microbe Bb Binds C3b C3 Convertase: C3bBb, C5 Convertase: C4b2bC3b C5b produced common late pathway, C1 binds 2 adj. Fc regions C2 →2b Classical C3 Convertase C4b2b (binds on microbe, not C1), Microbe Fc regions of Ab's ↑accessible to Complement C1 binds 2 adj. Fc regions, ↑[C3b] add'l C3b bind microbe C5 Convertase: C4b2bC3b, C3 Convertase: C3bBb additional C3 Binding ↑[C3b], IgG or IGM bind antigens Microbe, Classical C3 Convertase C4b2b (binds on microbe, not C1) additional C3 Binding ↑[C3b], common late pathway C5b C6,C7, C8,C9, C1 binds 2 adj. Fc regions C4 →C4b Classical C3 Convertase C4b2b (binds on microbe, not C1), C6,C7, C8,C9 Poly C9 MAC ATTACK, C5 Convertase: C3bBbC3b C5b produced common late pathway, Factor B Bb Binds C3b C3 Convertase: C3bBb, ↑[C3b] add'l C3b binds C5 Convertase: C3bBbC3b