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This Concept Map, created with IHMC CmapTools, has information related to: Immune Response - Adaptive - BCells, Class Switching (mostly Follicle B Cells) INF-γ (CD4/8 (TH1), NK) IgG, BCells endocytose specific antigen & present on MHC2 antigen specific interaction helper Tcells activate B cells w/ CD40L & cytokines, B-Cells (naive express IgM & IgD) activation w/ Antigen ↑cytokine receptors & low level IgM secetion, memory cells 2nd exposure plasma cells, IgM Affinity Maturation (somatic hypermutation) in germinal centers memory cells, IgM expressed or secreted classical complement activation, IgM Affinity Maturation (somatic hypermutation) in germinal centers plasma cells, 2nd Signal (cytokines, Compliment C3b- fn similar to costim of APC's) activation w/ Antigen ↓chemokine sensitivity -migrate out of LN, B-Cells (naive express IgM & IgD) activation w/ Antigen protein antigens: ↑interact w/ helper T, IgG Affinity Maturation (somatic hypermutation) in germinal centers memory cells, Class Switching (mostly Follicle B Cells) Marginal Zone B Cells (absence of CD40L) IgM, Differentiated CD4 effector Tcells migrate from peripheral lymphoid antigen specific interaction helper Tcells activate B cells w/ CD40L & cytokines, IgA Affinity Maturation (somatic hypermutation) in germinal centers plasma cells, 2nd Signal (cytokines, Compliment C3b- fn similar to costim of APC's) activation w/ Antigen T-Cell Indept Diff, IgA mucosal immunity Secretions, 2nd Signal (cytokines, Compliment C3b- fn similar to costim of APC's) activation w/ Antigen ↑ B7 costim. (2nd signal for Tcell), Adaptive Response B Cell B-Cells (naive express IgM & IgD), 2nd Signal (cytokines, Compliment C3b- fn similar to costim of APC's) activation w/ Antigen protein antigens: ↑interact w/ helper T, 2nd Signal (cytokines, Compliment C3b- fn similar to costim of APC's) activation w/ Antigen BCells endocytose specific antigen & present on MHC2, helper Tcells activate B cells w/ CD40L & cytokines differentiation Class Switching (mostly Follicle B Cells)