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This Concept Map, created with IHMC CmapTools, has information related to: nephritic syndrome, nephritic syndrome characterized by some proteinuria (ɭ) and edema, but not as severe as in nephrotic synd, Acute Postinfectious (Poststreptococcal) Glomerulonephritis features typically 3-14yrs old NS begins abruptly 10-14d (***) after throat or skin infxn assoctd w/ recent strept infx (grp A beta-hemolytic) but others can cause, SLE lupus nephritis characteristic in severe LN LM, IgA nephropathy (Berger Disease) <berh-zhay'> associated with incrsd freq in those w/ celiac disease w/ liver disease, nephritic syndrome nrml complements Anti-GBM (Goodpasture's), glomerular deposition of immune complexes features hypocomplementemia granular deposits of IgG and complement on the GBM, Anti-GBM (Goodpasture's) renal+pulm. Goodpasture's Disease, Acute Postinfectious (Poststreptococcal) Glomerulonephritis clinical course kids:excellnt prognosis full recovery adults:worse prognosis some progressive dz, Acute Postinfectious (Poststreptococcal) Glomerulonephritis morphology LM: most characteristic change: uniformly incrsd cellularity of glomerular tufts EM: sub-epithelial humps *** against GBM. biggr than in membranous nephritis immunofluorescence: granular deposits of IgG and complement, nephritic syndrome characterized by hematuria - dysmorphic red cells and RBC casts in urine, IgA nephropathy (Berger Disease) <berh-zhay'> Tx ACEI /ARBs to reduce proteinuria, Fish Oil, Steroids for patients presenting with nephrotic syndrome or ARF 20 – 50 % pts w/ proteinuria have progressive renal disease, nephritic syndrome characterized by HTN, IgA nephropathy (Berger Disease) <berh-zhay'> differs from Henoch-Schonlein purpura IgA neph involves only renal HS purpura is systemic, prolif of cells in glomeruli ->leukocytic infiltrate inflmm rxtn injures cap walls dcrs GFR, nephritic syndrome nrml complements IgA nephropathy (Berger Disease) <berh-zhay'>, typically 3-14yrs old NS begins abruptly 10-14d (***) after throat or skin infxn assoctd w/ recent strept infx (grp A beta-hemolytic) but others can cause diff in days after illness Most common cause of recurrent or persistant hematuria worldwide Primarily in adolescents and young men Episodic, recurrent hematuria; have episodes of gross hematuria May occur 1-3 days after a viral like GI or URI illness Mild proteinuria; rarely nephrotic syndrome Elevated IgA levels in 50% of patients chronic, low-level disease (lupus n is severe, acute), EM differentiation of diseases depostis/humps located subendothelial lupus nephritis IgA nephropathy, prolif of cells in glomeruli ->leukocytic infiltrate inflmm rxtn injures cap walls RBC into urine, Acute Postinfectious (Poststreptococcal) Glomerulonephritis presentation abrupt onset oliguria, edema malaise slight fever, nausea, NS gross hematuria smoky brown urine some proteinuria (constant feature) serum complement levels low during active phase serum anti-streptolysin O antibody titers elevated in poststrept cases, nephritic syndrome characterized by oliguria reciprocal fluid retention azotemia