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This Concept Map, created with IHMC CmapTools, has information related to: 10.11 Smoke Inhalation Case, Treatment options include hyperbaric oxygenation (HBO), CN off of methemoglobin forming thiocyanate, MELAS is a genetic disorder, Treatment options include Cyclooxygenase inhibitor, isocitrate dehydrogenase causing cessation of TCA cycle, 41 Yr Old female victim of fire has objective findings, Smoke inhalation whose Treatment options, amyl nitrite converting Hb to methemoglobin, Hemoglobin with Affinity 240 times that of oxygen, Standard free energy through Transfer of electrons from NADH to O2, Increased NADH/NAD+ ratio in mitochondria stimulating Anaerobic glycolysis, Increased NADH/NAD+ ratio in mitochondria which inhibits isocitrate dehydrogenase, oxidized state called Methemoglobin, Lactate dehydrogenase which releases NAD+ in the cytosol, Treatment options include IV fluid injeciton, inability of cells to function which results in severe brain injury, Carboxy Hemoglobin of 28% which suggests Carbon monoxide poisoning, sodium nitrite supplemented with methylene blue, hyperbaric oxygenation (HBO) which reduces systemic hypoxic state, Fe2+ ion on hemoglobin causing Hypoxia