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This Concept Map, created with IHMC CmapTools, has information related to: 11.15 - Biochem - G6PD Deficiency (Group Map), unconjugated bilirubin which normally becomes conjugated by binding to albumin, NADP+ as coenzyme/ electron acceptor, G6PD Deficiency consistent with symptoms, including Heinz Bodies, increased extravascular hemolysis contributing to total serum bilirubin 19 mg/dL (normal ə.9 mg/dL), attach to RBC membranes making them rigid/ less deformable RBCs, increased ratio of NADP+/NADPH contributing to decreased levels of reduced glutathione (GSH), increased intravascular hemolysis predominantly seen in acute hemolytic episodes, G6PD Deficiency consistent with symptoms, including total serum bilirubin 19 mg/dL (normal ə.9 mg/dL), increased immature RBC count consistent with insufficient healthy RBC in blood, NADPH which is competitive inhibitor, precipitated denatured hemoglobin due to accumulation of hydrogen peroxidase, irreversible oxidation of glucose-6-phosphate, increased oxidative metabolites in cell resulting in increased intravascular hemolysis, Pentose Phosphate Pathway whose rate-limiting enzyme is Glucose-6-Phosphate Dehydrogenase, 50-yr-old female presents with total serum bilirubin 19 mg/dL (normal ə.9 mg/dL), Glucose-6-Phosphate Dehydrogenase when deficient, leads to decreased levels of NADPH, decreased levels of reduced glutathione (GSH) leads to increased oxidative metabolites in cell, total serum bilirubin 19 mg/dL (normal ə.9 mg/dL) contributes to jaundice, decreased levels of reduced glutathione (GSH) affects normal maintenance of REDUCED STATES of SULFHYDRYL GROUPS in proteins (including hemoglobin), competitive inhibitor of Glucose-6-Phosphate Dehydrogenase