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This Concept Map, created with IHMC CmapTools, has information related to: LDL receptor def.cmap, expression of both mutant alleles which exacerbates levels to 1150mg/dL cholesterol at age 3, enterohepatic circulation is responsible for the recylcing of bile acids, low free intracellular cholesterol (FIC) is sensed by SCAP/SREBP complex in the ER, cleavage of complex releasing SCAP, plasma cholesterol levels which is carried by LDL, glycerol to be used by hepatocytes, parents with heterzygous FH genotype each possess one functional allele, bile production by activity of 7-alpha hydroxlase, cholesterol levels (300-400mg/dL) suggests parents with heterzygous FH genotype, low fat/cholesterol diet with statin treatment options for 10 year old girl, IDL are coated with ApoB100, SRE causing the activation of trasncription of HMG CoA reductase gene, LDL cannot bind to truncated, non-functional LDL receptor protein, 10 year old girl is found to have normal triglyceride levels, HDL donates Apo E, nucleus where it binds to SRE, plasma and is then tagged with Apo E, premature coronary artery disease leads to clinical diagnosis of homozygous familial hypercholesterolemia, TG hydrolization resulting in formation of IDL, degraded which would prevent uptake of plasma cholesterol into cells