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This Concept Map, created with IHMC CmapTools, has information related to: B Cell Development, Heavy Chain comprised of Constant Region, IgD via Alternative Splicing of 3 or 4 C heavy, Antigen Binding Site on T Cell Receptor, Non-Covalent Forces including H+, Checkpoint 1: Complete Heavy Chain fail leads to Apoptosis, Pathogen degraded via proteosome, preseted on MHC, Naive B Cell into Effector B Cell, Small Pre B into Immature B, B Cell developed as Pluripotent Hematopoietic Stem Cell (in bone marrow), Homogenous BCR produces High Avidity, Effector B Cell via Alternitive Splicing, "Mu" Heavy Chain Is Made enters ER, Dendritic Cell (in tissue, travels to secondary lymph) phagocytoses Pathogen, Checkpoint 2: Complete Light Chain fail leads to Apoptosis, Early Pro B into Late Pro B, Constant Region varies to make IgE, IL7 promotes V-DJ Rearrangement (variable), Stromal Cell (in bone marrow) support Pluripotent Hematopoietic Stem Cell (in bone marrow), IgM on surface via ER, Epitope binds to Antigen Binding Site