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This Concept Map, created with IHMC CmapTools, has information related to: 1.26 Immunology Review, IL-1 circulate in blood then bind to complementary ADHESION MOLECULES on tissue cells (with B2 subunit), IL-12 which activates NK cells (lymphocyte), pathogen and TNF-a in circulation causing systemic vascular leak and systemic edema, TLR4/MD2/CD14/LPS complex on macrophage surface then MyD88 binds to TLR4, IL-1 which increase permeability of endothelial walls of blood vessels, Pathogen infects host tissue then pathogen is recognized by a NEUTROPHIL, bind to complementary T cell and then together divide and differentiate into EFFECTOR T CELLS, apoptosis of neutrophil leading to phagocytosis by macrophage, C-REACTIVE PROTEIN (CRP) which enhance complement fixation at pathogen surfaces, IL-1 cause fever, increased CYTOKINE production mainly IFN-gamma, increased transcription of INFLAMMATORY CYTOKINES including CXCL8 (chemokine), degradation of pathogen leading to phagocytosis by macrophage, Type I interferon receptor on the infected cell (same cell that produced IFN-B) can also bind NK cells, blood clotting and blockage of local blood vessels which prevents pathogens from entering blood, TNF-a cause increased synthesis and secretion of ACUTE-PHASE PROTEINS from liver, increased transcription of INFLAMMATORY CYTOKINES including IL-1, vascular endothelial cells to make PLATELET-ACTIVATING FACTOR (PAF) resulting in blood clotting and blockage of local blood vessels, TLRs commonly TLR3, CXCL8 (chemokine) circulate in blood then bind to complementary ADHESION MOLECULES on tissue cells (with B2 subunit)