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This Concept Map, created with IHMC CmapTools, has information related to: Molecular Targeted Chemotherapies, Bevacizumab ADME IV administration, Non-linear Pharmacokinetics, Trastuzumab (Herceptin) Toxicities Hypersensitivity Rxn (Dermatological), CV Rxn, Pulmonary Fibrosis, "Newer" Agents Boost Immune system Cytokines, Tyr Kinase Inhibitors Broad Spectrum GIST/RCC Sunitinib, Ipilimumab ADME IV administration, Non-linear Pharmacokinetics, Sunitinib Toxicities Generally Mild, N&V Edema, Muscle Cramps Neutropenia, Thrombocytopenia, Bortezomib Tox P. neuropathy hematological, Rituximab ADME IV administration, Non-linear Pharmacokinetics, Rituximab Toxicities Hypersensitivity Rxn (Dermatological), CV Rxn, Pulmonary Fibrosis, Proteosome Inhibitor Inhibits (NF)-KB Bortezomib, Differentiation Agents PML/RAR Arsenic trioxide, Targeted Chemotherapy Interfere disrupted signaling Signal Transduction Inhibitors, Cytokines IL-2, Tyr Kinase Inhibitors EGFR Lung Gefitinib, Vemurafenib ADME Quick to become Resistant, Antibodies HER2 Breast Trastuzumab (Herceptin), Sorafenib DLT Myelosupression, Ser/Thr Kinase Inhibitors B-Raf Vemurafenib, Tyr Kinase Inhibitors EGFR Lung Erlotinib, "Newer" Agents Angiogenesis TNF Thalidomide