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This Concept Map, created with IHMC CmapTools, has information related to: b4 GOUT, guanine HGPRT GMP, swollen, red toe caused by localized inflammation and pain, microtophi or clumps of negatively charged monosodium urate monohydrate crystals, febuxostat inhibits xanthine oxidase, Chris Turtle presents with elevated serum uric acid (hyperuricemia), AMP deaminated IMP, hypoxanthine converted to xanthine oxidase, GOUT treated with allopurinol, allopurinol metabolized in the kidney, neutrophil infiltration and buildup of inflammatory exudate within joint space/ soft tissue, overproduction of uric acid, PRPP glutamine phosphoribosyl amidotransferase 5-phosphoribosyl 1-amine, acute EtOH ingestion can potentiate flare ups of GOUT, xanthine oxidase to uric acid, lactic acid competes with uric acid for renal transporters, hypoxanthine HGPRT GMP, interaction with dendritic cells and macrophages leading to IL-1 production, obese often associated with overproduction, GOUT characterized by monosodium urate monohydrate crystals, GMP converted to guanosine