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This Concept Map, created with IHMC CmapTools, has information related to: Coronary and Pulmonary Blood Flow, Increasing myofilament sensitivity to calcium Result from changes in Rate of MLC dephosphorylation by MLC phosphatase, Blood Flow ???? Coronary Circulation, Zone 2 Defined as Ppa > PA > Ppv, Right coronary artery Branches into Right marginal branch, Endothelium-derived contracting factor (EDCFs) ???? Thromboxane, Atrial branch Branches into Sinoatrial nodal branch, Coronary Circulation Is composed of VSM cells, Increased lung volume causes decreased resistance + Total resistance is lowest at FRC, Endothelin Causes vasoconstriction by Increasing myofilament sensitivity to calcium, Highly compliant Because of Recruitment, Nitric oxide Causes vasodilation by Decreasing myofilament sensitivity to calcium, Coronary Circulation Blood flow depends on Perfusion pressure in aorta, PA > Ppa > Ppv Affects resistance of vasculature such that Perfusion is greater at base of lungs, less at apex of lungs, Endothelium-derived contracting factor (EDCFs) ???? Endothelin, Coronary Circulation Is regulated by Local effects, Pulmonary Circulation Is actively regulated by primarily Endothelins (vasoconstriction), Humoral effects Including Norepinephrine, Increasing intracellular Ca2+ concentration Result from changes in Ca2+ release, Pulmonary Circulation Distribution is influenced by Gravity, Pulmonary Circulation Is regulated by Humoral effects