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This Concept Map, created with IHMC CmapTools, has information related to: Frank Teller (B13), Body Temperature lack of T3/T4 manifests as Cold Intolerance, ESR of 35 mm (Elevated), DIT coupling creates T3, Primary Hypothyroidism due to dysfunction of Folicular Cells (Located in Thyroid), Autoimmune Disorder targeting Thyroid Specific Antigens (TPO, Tg), Frank Teller is a Male, Anti-Thyroid Peroxidase (Anti-TPO) of 150 IU/mL (Elevated), Thyroid Release Hormone (TRH) through Hypothalamo-hypophyseal portal system, Frank Teller presents with Dry, Scaly Skin, Thyroid Hormone Receptors activation promtes Growth and Differentiation, Self-Thyroid Antibody tags self-antigens for destruction such as Folicular Cells (Located in Thyroid), Thyroid Specific Antigens (TPO, Tg) brought to lymphoid organ by Antigen Presenting Cells (APCs), MIT coupling creates T3, Frank Teller presents with Bradycardia, Frank Teller underwent Diagnostic Tests, Frank Teller presents with Painful and Swollen Joints, Naive T Cells undergo Central Tolerance, Th2 Cells activate B Cells, Hypothalmus release Thyroid Release Hormone (TRH), Folicular Cells (Located in Thyroid) uptake from blood Iodide