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This Concept Map, created with IHMC CmapTools, has information related to: Etiology and Pathogenesis, adhesion molecules such as Intracellular adhesion molecules (ICAMs, macrophages consists of (dominantly), Established Gingivitis also known as Established Lesion (with no bone loss), Early Lesion is characterized by increase of dilated vessels, to increase bone marrow production of neutrophils and various proteins involved in host defense, F. nucleatum ???? Fusobacterium sp, Periodontal Disease is by removing the Etiologic Factors, Changes in structure whch include Periodontal fiber damage, Early Lesion is characterized by epithelial rete pegs, Periodontitis is characterized by Increased immune response, virulence factors activate CT cells, IL-10, TGFβ (Transforming Growth Factor), IL-1ra(receptor antagonist) and TIMPs (Tissue Inhibitors of Metalloproteinases) LOW Associated with Disease, adhesion molecules expressed on leukocytes, Gram Postive Filaments such as Actinomyces sp., Changes in structure whch include Apical migration of junctional epithelium, TH1 cells producing cytokines, associated with health such as in Clinically healthy gingiva, chemical mediators inducing Acute Inflammatory Response Phase, Early Lesion is characterized by proliferation of the basal cell epithelium, Periodontal Disease Periodontitis