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This Concept Map, created with IHMC CmapTools, has information related to: Formatted, a keystone pathogen may be central to disease process, Changes in structure such as Continued loss of collagen, B cells to mature into plasma cells, Reversible adhesion through Van der waals forces, Host response that results to Increased inflammation, Dysbiosis also known as "microbial shift", leukocyte migration regulated by adhesion molecules, collagen depletion which accomodates 5% CT Volume, TH2 cells producing cytokines, Removing the bacterial plaque through Oral hygiene procedures, Early Gingivitis can be see having bleeding on gentle probing, virulence factors activate epithelial cells, Irreversible adhesion with Initial colonizers, TREATMENT of Periodontal Disease, DEVELOPMENT OF GINGIVITIS is initiated by Biofilm or plaque formation, virulence factors activate endothelial cells, cell-mediated immunity which involves chemical mediators, destructive action that is to stimulate osteoclastic bone resorption, Periodontitis is characterized by Changes in structure, Change the biological and physical properties such as pH and free energy