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This Concept Map, created with IHMC CmapTools, has information related to: concept map, adhesin receptors of inital colonizers, Histopathology Periodontal Pocket, events that compromise pathogenesis initiated, driven, regulated by chemical mediators, a consortium of bacteria participate in the disease Some of which are Moderately Pathogenic, 4) Regulation and Resolution Phase shows shift from gingivitis to periodontitis, Histopathology Collagen depletion, Extension of the inflammatory infiltrate happens laterally (around the tooth), IL-1, TNFα, INF γ, PGE2, and MMPs low health, Microbial Composition where increased microbial load and increase in gram negative bacteria or organisms, Keystone Pathogen Hypothesis indicates that low-abundance microbial pathogens, Damage surrounding cells and CT structures form of Indirect tissue destruction, preventing dessication by coating the outer surface of the tooth & mucosal surfaces, Histopathology Large number of plasma cells, Calculus/tartar elimination thus lessened plaque retention, Pathogenesis Inflammatory and immune processes, Highly Pathogenic such as ● Aggregatibacter actinomycetemcomitans serotype b ● Porphyromonas gingivalis ● Tannerella forsythia ● Treponema denticola, Histopathology Increased fluid (gingiva crevicular fluid) exudation, Biofilm disruption thus pathogenic microorganisms are reduced, removal of plaque and calculus from Subgingival area, selectins, adhesion molecules, and chemoattractant production of chemical mediators