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This Concept Map, created with IHMC CmapTools, has information related to: Periodontal Diseases Concept Map, Clinically Healthy Gingiva how it progresses within 2-4 days of plaque build up, Periodontitis how it progresses failed resolution of inflamation, Keystone Pathogen Hypothesis includes concept of dirupted homeostasis, RANKL binding to the OPG, instead of the preosteoclast if presence of mature osteoclast already, seldomly achieved in the human body due to no inflammation, concepts that diseases occur due to increase in the number of pathogens, 1. formation of acquired pellicle that coats the surface of the teeth, Local factors decrease the number of Osteoprotegerin (OPG) however Host has lots of OPG, interspecies communication leads to Dysbiosis, 1. formation of acquired pellicle that allows for attachment of microorganisms, some presence of inflammation as evidenced by presence of gingival sulcus, micro plaque releases lipopolysaccharides and endotoxins, Cytokines - TNF α, IL6, IL-1α & IL-1β at high levels, induces Connective Tissue Destruction, Dysbiosis views periodontitis as a community of disease reliant upon an entire dysfunctional microbiota, PERIODONTAL DISEASES can be treated by removing the causative agents, Periodontitis associated MOs Treponema denticola, concepts that diseases occur due to decrease in the number of beneficial symbionts, Early Gingivitis Clinically observed as Gingival Swelling, Local Factors (IL-1, PGE2, Tissue Necrosis Factor (TNF)) mechanism Local factors decrease the number of Osteoprotegerin (OPG), Proinflammatory cytokines induce vascular changes results to Increased flow of GCF