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This Concept Map, created with IHMC CmapTools, has information related to: Robert_Dillon_C3_Final, MHC Molecule MHC Class I molecules are MHC molecules composed of an alpha chain and a beta-2 microglobulin MHC Class I molecules, IgE is bound to mast cells via the Fc portion. When an antigen binds IgE on the mast cell it degranulates which causes a release of Histamine which can lead to Anaphylaxis, Cyclosporine Cyclosporine, Basiliximab, and a corticosteroid are administered to prevent transplant rejection Corticosteroids, Complement complement activated in both Type II and III hypersensitivity as part of the immune response, causing unintentional tissue damage Type III hypersensitivity, Vasculitis is a symptom of IgG-mediated hypersensitivity IgG, Type III hypersensitivity circulating Ab-Ag complexes leads to localized abscesses or necrotizing vasculitis Vasculitis, MHC Class I molecules MHC class I molecules present peptide antigens to T-cytotoxic cells T-cytotoxic cells (CTLs), MHC Molecule MHC class II molecules are MHC molecules found on the surface of antigen-presenting cells MHC Class II molecules, Antivenom administration of antivenom can elicit an immediate hypersentivity, which can be life-threatening Anaphylaxis, Myasthenia Gravis younger patients w/ Myasthenia Gravis are at increased risk for developing thymic abnormalities, such as hyperplasia and thymoma Thymus, TCR the TCR requires a specific dose of an antigen to be activated, an important regulation of central tolerance Central Tolerance, Thymus central tolerance involving immature T-cells occurs in the cortex and medulla of the thymus Central Tolerance, IgM IgM/IgG interaction with cell membranes or the extracellular matrix leads to Ab-mediated cytotoxicity Antibody-mediated, TCR TCRs bind to peptide antigens that are complexed with the MHC molecules through theimmunological synpase MHC Molecule, Antibody-mediated reaction leads to painless muscle weakness, diplopia and ptosis in Myasthenia Gravis, Robert Dillon, 28 y.o. Hispanic Male patient presents w/ Fever, Fever can be a result of activation of inflammatory pathways activated by Bradykinin, Antivenom are antibodies that follow the passive immunity model Antibody-mediated, Sulfonamides an acute allergic reaction associated w/ Sulfonamides is Stevens-Johnson Syndrome (SJS), Type II hypersensitivity is mediated by the antibodies IgG