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This Concept Map, created with IHMC CmapTools, has information related to: Hershel_Greene_C3, Partial thromboplastin time (PTT) PTT is a measure of the intrinsic pathway that records the time to fibrin clot Intrinsic pathway, Serotonin release assay (SRA) SRA is a platelet-activation test to confirm the diagnosis of HIT Heparin-induced Thrombocytopenia (HIT), Fc Receptor the Fc receptor on platelets binds to the constant region of an immunoglobulin Platelets, Warfarin decreases levels of reduced Vitamin K, which results in the reduced activation of various clotting factors, including Factor VII Factor VII, Vascular injury exposes subendothelium which releases factors to start coagulation Tissue Factor, Heparin-induced Thrombocytopenia (HIT) targets the heaprin-platelet factor 4 complex and induces a hypercoagulable state IgG, Prothrombin Factor Xa converts Prothrombin to Thrombin in the presence of Factor Va Thrombin, Hematocrit (Hct) a low Hct level can produce symptoms of anemia, including fatigue, due to decreased Hemoglobin Fatigue, Heparin an anticoagulant that potentiates thrombin inhibition Thrombin, Fatigue low Hb causes decreased oxygen-carrying capacity of RBCs and decreased iron in blood, contributing to fatigue Hemoglobin, Thrombin a systemic thromboembolism increases the risk for infarction within the arterial system Myocardial infarction, Antithrombin (AT) prevents coagulation via bringing to thrombin/Factor X (as well as VII, IX, XI, XII) and being the primary inhibitor for thrombin Thrombin, Partial thromboplastin time (PTT) PTT is measured to monitor heparin therapy because heparin binds antithrombin, which activated coagulation factors in the intrinsic pathway Heparin, Thrombin can pass to the main pulmonary artery, straddle bifurcation, or pass into smaller branching arteries, causing occlusion Pulmonary embolism, Extrinsic pathway activated via tissue damage that causes the blood to leave the vasculature by releasing tissue factor III which goes on to activate factor VII Factor VII, Intrinsic pathway the intrinsic pathway is activated by damage from within a blood vessel Vascular injury, Endothelium damage leads to endothelin release which causes vasoconstriction leading to the next steps of platelet adhesion Platelets, D-dimer test D-dimer is a fibrinolysis degradation product that is useful in diagnosing Clotting Disorders, Hershel Greene 65 y.o. male had positive results of the PF4 heaprin-ELISA which indictates that he has HIT PF4 ELISA, Fibrinogen one of the final steps of the clotting cascade is when Fibrinogen is converted to Fibrin via Factor I (Thrombin) Fibrin