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This Concept Map, created with IHMC CmapTools, has information related to: CBL1 Ruth Degeneress, Osteoclasts are involved in the breakdown of Hyaline cartilage, Morning stiffness lasting less than 30 minutes is a clinical sign of Osteoarthritis, HLA-DRB1 is a gene that transcribes for MHC II receptors, Immune complexes that are present within Synovium, Ruth Degeneress a 35 y/o Caucasian Female presents to the primary care office with symmetric painful joints, Asymmetric arthritis was not present in this case symmetric painful joints, Fc fragment of the antibody IgG, CRP (C-reactive protein) are non-specific inflammatory markers that would be elevated in Pregnancy Arthralgia, IL-1 stimulate synovial cells to release proteases, leading to breakdown of Hyaline cartilage, History of viral illness tested negative for Lyme titer, Ruth Degeneress a 35 y/o Caucasian Female presents to the primary care office with History of viral illness, Ruth Degeneress a 35 y/o Caucasian Female presents to the primary care office with Symmetrical polyarthritis, Ruth Degeneress a 35 y/o Caucasian Female is positive for Rheumatoid factor, Synovial T-helper cells releases inflammatory cytokines IFN-gamma, Rheumatoid arthritis is initiated by Synovial T-helper cells, TNF inhibtion of has anti inflammatory action, CRP (C-reactive protein) are non-specific inflammatory markers that would be elevated in Infectious arthritis, CD20 proteins inhibtion of has anti inflammatory action, symmetric painful joints is a common indicator of Rheumatoid arthritis, Biologic TNF DMARDs which includes Etanercept