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This Concept Map, created with IHMC CmapTools, has information related to: C-1 Case 4 Degeneress, Bone erosion Histology changes: This pannus is a mass of edematous synovium, inflammatory cells, granulation tissue, and fibroblasts that grow over cartilage and erodes it Swan neck deformity, Synovial T-helper cells Activated T-helper cells secrete IFN-gamma IFN-gamma, Ruth Degeneress 35 y.o.f CC: "Painful joints" Social Hx Second-hand smoke, Synovial T-helper cells Lymphocytes, antibodies and immune complexes enter the joints, causing a release of cytokines, pannus formation, and destruction of bone cartilage Morning stiffness, Laboratory Diagnostics Laboratory Assay indicated abnormally high concentrations (27 mg/dl) of CRP (C-reactive protein), Rheumatoid Arthritis Chronic symptoms Swan neck deformity, Second-hand smoke Smoking may promote citrullation of self protines, triggering autoantibody production Anti-Cyclic Citrullinated Peptide (Anti-CCP), Macrophages Can differentiate into Osteoclasts, Rheumatoid Arthritis Chronic symptoms Pannus, Which causes B-cell Depletion can lead to depletion of IgM, IL-1 Activates enzymes like proteases and MMPS that break down collagen Collagen, Rheumatoid Arthritis Medications Used to Supress Inflammation and treat RA Biologic non-TNF DMARD, B-cells Lymphocytes, antibodies and immune complexes enter the joints, causing a release of cytokines, pannus formation, and destruction of bone cartilage Bone erosion, B-cells Lymphocytes, antibodies and immune complexes enter the joints, causing a release of cytokines, pannus formation, and destruction of bone cartilage Morning stiffness, HLA-DRB1 Most important genetic risk factor for RA. Presence of gene leads to 50% risk of developing RA Rheumatoid Arthritis, Fc fragment IgM and IgA autoantibodies bind to the Fc region on IgG which is known as RF Rheumatoid Factor, Rheumatoid Arthritis Chronic symptoms Symmetrical polyarthritis, Bone erosion Histology changes: This pannus is a mass of edematous synovium, inflammatory cells, granulation tissue, and fibroblasts that grow over cartilage and erodes it Synovium, IgG IgG deficiency could lead to increased infections Infectious arthritis, Macrophages Macrophages secrete proinflamamtory factors as a response to a detected antigen IL-1