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This Concept Map, created with IHMC CmapTools, has information related to: week 16, mesocortical pathway low dopamine in the mesocortical pathway leads to negative symptoms Negative symptoms, D2 receptor Block of D2 receptor in mesocortical pathway worsens negative symptoms mesocortical pathway, Schizophrenia hypoactivity from VTAto DLFPC is a component of schizophrenia in the mesocortical pathway mesocortical pathway, Olanzapine Both drugs used to treat sx of schizophrenia Haloperidol, glutamine Glutamate produced from glutamine is crucial for the functioning of NMDA receptors, which are involved in synaptic plasticity & memory. NMDA receptor, MME score of 23 Score of 23 or less, indicates cognitive impairment & is indicatative of a psychotic episode Psychotic episode, prolactin Both hormonal dyregulation involved in antipysch tx Hyperthyroidism, Haloperidol A typical antipsychotic that stops Hallucinations, G protien coupled receptor Many GPCRs are dopamine receptors, which play critical roles in neurotransmission & brain function. dopamine, dopamine Pathway involves dopamine neurotransmission impacting cognition and emotion. mesocortical pathway, Extrapyramidal symptoms EPS often mimic symptoms of Parkinson’s disease, such as tremors, rigidity, & bradykinesia. Parkinsonism, Urine drug screen came back positive for PCP, Positive symptoms False beliefs on inaccurate perception of reality Delusions, serotonin One of the serotoning receptors associated with weight gain 5-HT2a receptor, Myxedema Myxedema monitored, checks for elevated TSH, indicative of underactive thyroid. thyroid stimulating hormone, Schizophrenia high dopamine in mesolimbic pathway leads to positive symptoms mesolimbic pathway, serotonin Serotonin regulates glutamate & GABA release Glutamate, Jack Dawson 25 yo male he/him/his Chief Complaint CC: “The police picked me up for some reason. They have probably been told to stop me.”, G protien coupled receptor GPCRs also include various serotonin receptors involved in mood regulation, appetite, & sleep. serotonin, mesolimbic pathway Increases DA in mesoL system, & decreases prolactin production prolactin