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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 6 merged, a phosphoinositol is an example of second messengers, SH2 group that binds to the growth factor receptor, Nuclear factor-κB (NF-κB) is normally bound to Inhibitor of NF-κB (IκB), Inhibitor of NF-κB (IκB) when phosphorylated is a target for Ubiquitylation, Cyclin D1 discussed further in Chapter 8, adaptor proteins e.g. Grb2, immediate early genes without protein synthesis that is de novo, serum activate signaling pathways, α sub-unit when activated separates from β sub-unit, a phosphoinositol causes membrane tethering of PH-containing molecules, cell surface to the nucleus, 150 target genes including IAP-1, Bad inhibits Apoptosis, tyrosine kinase receptor e.g. Sevenless, Grb2 contains one SH2 group, STAT proteins when phosphorylated dimerize to form Transcription factors, Focal adhesion kinase (FAK) when phosphorylated binds Src, Heterotrimeric G-proteins are composed of γ sub-unit, signaling pathways are deregulated by oncoproteins, Ras signaling cascade begins with a tyrosine kinase receptor