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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 6 Merged Map, a phosphoinositol is an example of second messengers, SH2 group that binds to the growth factor receptor, Nuclear factor-κB (NF-κB) is normally bound to Inhibitor of NF-κB (IκB), Inhibitor of NF-κB (IκB) when phosphorylated is a target for Ubiquitylation, serum activate signaling pathways, immediate early genes without protein synthesis that is de novo, adaptor proteins e.g. Grb2, Cyclin D1 discussed further in Chapter 8, α sub-unit when activated separates from β sub-unit, cell surface to the nucleus, a phosphoinositol causes membrane tethering of PH-containing molecules, Bad inhibits Apoptosis, 150 target genes including IAP-1, Grb2 contains one SH2 group, tyrosine kinase receptor e.g. Sevenless, STAT proteins when phosphorylated dimerize to form Transcription factors, signaling pathways are deregulated by oncoproteins, Heterotrimeric G-proteins are composed of γ sub-unit, Focal adhesion kinase (FAK) when phosphorylated binds Src, Grb2 contains two SH3 groups