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This Concept Map, created with IHMC CmapTools, has information related to: group cmap, E-CDK2 prepares proteins for the centrosome, Smad3-Smad4 comples activates transcription of p15INK45, p15 ink4B inhibits D-CDK4/6, E-CDK2 forms Hyperphosphorylated pRB, hypophosphorylated depending on the phase of the cell cycle, TGF-beta antagonizes tumor progression, pRb gets hyperphosphorylated, cell cycle clock requires regulation of the cell cycle clock, Myc prevents transcription of Miz-1, restriction point aka R point, T oncoprotein have cellular targets, cellular targets are members of pocket proteins, p21Cip1 deactivates A-CDK2, TGF-beta upregulates the transcription of p21Cip1, cell cycle includes mitosis, cyclin E phosphorylates and deactivates p27Kip1, tumor progression ex CML, E-CDK2 hyperphosphorylates pRB, pRb phosphorylation during cell cycle affects actions of pRb, actions of pRb are mostly regulation of the cell cycle clock