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This Concept Map, created with IHMC CmapTools, has information related to: 10 merged, senescence can be postponed by expressing hTERT, sequence exchange between telomeres aka copy choice mechanism (fig 10.30), detectable in 85-90%, Humans requires introduction of SV40 large T oncogene, Crisis results in Apoptosis, Cell-Lineage is studied using Caenorhabditus Elegans, Generational Clock could cause cells to enter Crisis, cancer cells can avoid crisis, holoenzyme consisting of several subunits including hTERT, Tumor Supressor Genes block Senesence, crisis aka loss of neoplastic growth program (fig 10.27), Overhang is found in a configuration termed T-Loop, Clonal is duscussed in Section 2.5, ALT mechanism 10.8 maintains Telomeres 10.5, telomerase allows for regeneration, Tumors contain cells which undergo Apoptosis, Cancer Cells depend on other Cell Types, Laboratory mice with inactivation of mTR, Cell-Physiologic Stresses limit Replication, Senescence 10.1 entry is controlled by Generational Clock 10.2